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The bottom line: Although most of the women given standard weight-loss counseling continued to gain weight over the ensuing 18 months, those given maintenance counseling were much more likely to stabilize their weight. By contrast, when these cases are settled, they are available to consumers before the patent expires 100% of the time. For example, Adderall XR, the first drug on the PIRG list, had a patent that expires in 2018. By their own calculations, after a settlement with consideration, the drug was available to consumers nine years before the patent expired. According to the analysis conducted by the IMS Institute for Healthcare Informatics released this week, generic-generated savings on Adderall XR was $211 million dollars from January 2013 to the end of its patent. Lipitor, also on the PIRG/Community Catalyst list, was available as a generic more than five years before the patent expired, and the IMS Institute analysis shows it will save nearly $23 billion before the end of its patent. That is why it is critical for consumers and policymakers to understand: they are getting more generic choices, years earlier, because of patent settlements with consideration. When we used the extract from that melon, we saw that it kills the breast cancer cells, said lead researcher Ratna Ray, a professor of pathology at Saint Louis University. But their work was done in a laboratory, not in humans, she noted.

Copenhagen, Denmark, August 19, 2013 / B3C newswire / � Nuevolution A/S announces a corporate update.<br/> Professor Dr. Jutta Heim has joined Nuevolution as Director and Senior Scientific Advisor to the Board of Directors.<br/> Dr. Heim worked for more than 20 years at Ciba-Geigy/Novartis (CH and US). At Novartis, she was involved in the successful development and launch of anti-thrombotic and fibrinolytic products. She established Novartis� molecular genetics department in oncology, became Novartis� Senior Scientific Expert in Molecular Biology and a member of the Research Management Board. Dr. Heim completed her career at Novartis heading the Novartis Lead Discovery Center with worldwide responsibility. From 2004 to 2009, Dr. Heim served as CSO at Basilea Pharmaceutica Ltd., a Swiss biopharmaceutical company focusing on anti-infectives, inflammation and oncology. From 2009 to 2013, she served as CTO and CSO at Evolva SA, where she led Evolva�s discovery activities and strengthened the development of its technology platform. She received a PhD from the University of T�bingen in 1981 and holds a professorship in Biotechnology at the Biocenter of the University of Basel. Prof. Dr. Heim is a member of the advisory board of ��Stiftung f�r Wissenschaftliche Forschung Universit�t Z�rich�� and a board member of Evolva SA.<br/> Nuevolutions board of directors is composed as follows:<br/> Stig L�kke Pedersen, Chairman of the Board.<br/> Viktor Drvota, Director, SEB Venture Capital, Head of Investment Area, Life Science.<br/> S�ren Lemonius, Director, Partner, Sunstone Capital.<br/> Jonas Brambeck, Director, Investment Manager, Industrifonden.<br/> Professor Dr. Jutta Heim, Director, Senior Scientific Advisor to the Board.<br/> Stefan Olofsson, Observer, SEB Venture Capital Investment Manager, Life Science and Technology.<br/> �Jutta�s significant expertise and input has already been well appreciated by management and our board�, said Alex Gouliaev, CEO of Nuevolution A/S. �We are certain that her experience from the Industry, broad insight into general drug discovery and in particular within oncology will add significant value to the company. We are very pleased that Jutta accepted our invitation to join our Board of Directors�.<br/> Stig L�kke Pedersen, Chairman of Nuevolution A/S said: �Given that Nuevolution A/S has developed its Chemetics� technology to a very advanced level, and is in the middle of the build-up of an own product pipeline, we are eager to add complementary know-how and skills to the organization, including the Board. Jutta represents an important and valuable contribution in this regard.�<br/> In June 2012, Nuevolution announced a new financing round of � 11 Million to establish an internal pipeline of drug candidates addressing important targets within oncology and inflammation.<br/> The appointment of Dr. Heim represents an integrated part of the overall strategy to strengthen the expertise of the company at all levels. Earlier in the year, Nuevolution announced the appointments of Sir Marc Feldmann (Kennedy Institute, UK); Professor Dr. Gordon B. Mills (MD Anderson Cancer Center, US) and Dr. Alan Collis (formerly Novartis and Aventis, US) as advisors to the company in target selection and planning of the pre-clinical research strategy.<br/> Nuevolution�s technology has now been successfully validated in several partnerships with big pharma and big biotech companies. The Chemetics� platform uses DNA labeling for the identification of potent and drug like substances from vast pools of up to one billion screening compounds.<br/> Proof-of-concept studies have been initiated for several of the internal programs that have emerged from current screening efforts. Going forward, the company will seek joint venture partnerships and out-licensing of these programs. In parallel with this, Nuevolution will continue to form partnerships around its platform technology.<br/> �We have a major focus on the progress of our internal programs and invest significantly in the establishing of our internal pipeline within oncology and inflammation�, said Thomas Franch, CSO of Nuevolution and continued �However, we also believe it is imperative to continue to expand our platform including the production of additional high-complexity compound libraries that address tough-to-drug targets.�<br/> Nuevolution has also initiated a scientific collaboration where Professor Dr. Robert J. Lefkowitz, a Duke Faculty member and HHMI employee and Nobel Laureate in Chemistry 2012 will act as principal investigator in the investigation of the biological mechanism of action of a specified GPCR drug target using Nuevolutions Chemetics� platform. This collaboration is by and between Duke University, Howard Hughes Medical Institute, Lexicon Pharmaceuticals and Nuevolution. McKee noted that the 770 cases reported is probably only the tip of the iceberg and the actual number of these incidents may be closer to 1,500 to 2,000 each year. These mistakes can also lead to financial outlay: According to the commission, leaving objects inside patients cost as much as $200,000 in medical liability payments for each case. The greatest risk factor is being around infected rodent populations, he said. Folks who live in rural areas and folks who have pets, where those pets can bring fleas into contact with them, are most likely to get sick. I think as long as we keep thinking about the use of social media in pharma as the execution of a communication strategy on top of an existing social-exchange platform such as �Twitter� or �YouTube,� this industry is really going to struggle with making this important communication channel work well for them. The problem lies in the very nature of these platforms, in that they are built for the purpose of enabling as much dialogue and sharing as possible with the minimum amount of friction. In addition, in order for these platforms to make money they must be able to scale effectively and efficiently. These two concepts � rapid-information exchange and scalability � makes these kinds of pre-existing, mass-media social platforms ill-suited for pharma�s highly constrained communication efforts.

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